God & Nature Magazine
  • Winter 2023 Issue
    • Letter From the Editors
    • Braden, A Modern Bestiary
    • Garte, Assembly Theory
    • Defoe, The Heavens Declare
    • Greenberg, Bonding
    • Barrigar, God's Big Story
    • Phillippy, Overcoming Paradox
    • Bostrom, Near
    • Clifford, Hidden Figures
    • Budek-Schmeisser, Completion
  • Fall 2022 Issue
    • Letter Fall22
    • Curry, Attentiveness
    • Russo, Deconstruction
    • Touryan, Four Forces
    • Mittchell, Three Words
    • Philippy, Math Theology Fall 22
    • Bostrom, Goodbyes
    • Clifford FAll 22
    • Linsley, Mystic Exile
    • Hall, A Call to Arms
  • Summer 2022 Issue
    • Letter Summer 2022
    • Engelking, Neurotheology
    • Kelley, Environmentalism
    • Garte, Sandpipers
    • Madison, Cultivating Contentment
    • Collins, Answers on Evolution
    • Touryan, Tentmakers
    • Oord, Ever-Creative God
    • Bostrom, Mentors
    • Clifford, Carbon and Sin
    • Campbell, Just, In Time
  • Past Issues
    • Spring 2022 Issue >
      • Letter from the Editors Spring 2022
      • Curry, Knowldege and Truth
      • Pinkham, On a Car Emblem
      • Murray, Candling the Egg
      • Carr, Music, Math, Religion
      • Smith, Wonder and Longing
      • Linsky, Cyber Service
      • Bostrom, Buteo
      • Obi, Coincidences
    • Winter 2022 Issue >
      • Garte &Albert Letter Winter 2022
      • Thuraisingham Pondering Invisible
      • Cornwell Mediations from Molecular Biologist
      • Fagunwa Blsck Scientist & Church Father
      • Garte A Dialogue
      • Gonzalez Being Human
      • Klein Naturalist in Two Worlds
      • Bostrom Creeds
      • Clifford Winter 2022
      • Ardern Contact Points
      • Cooper Imagine No Christmas
    • Fall 2021 Issue >
      • Garte &Albert Letter Fall2021
      • Johnson, God Winks
      • Cottraux, Ancient Aliens
      • Arveson, Anti-Vax Email
      • Gammon, Evolutionary Insights
      • Mitchell, No One Told Me
      • Rummo, Faith in the Invisible
      • Bostrom, Fall Furrows
      • Lemcio, A Franciscan Weekend
      • Funk, Plant Haiku
      • Robinson & Lim, Who is God?
    • Summer 2021 Issue >
      • Garte &Albert Letter Sum2021
      • Warren, Immunization and Salvation
      • Defoe, Bernard Ramm
      • Cornwell Canine to Divine
      • Mix, Running with Nature
      • Pinkham, Scuba Divers
      • Cao, Physics and Bible
      • Bostrom, Sugar Birds
      • Clifford Sum21
      • Oostema, Evolution of Faith
      • Hall, Generation upon Generation
    • Spring 2021 Issue >
      • Garte and Albert Letter Spring 2021
      • Loikanen, Divine Action
      • Madison, Humus and Humility
      • Lappin, Puddles and Persons
      • Cornwell, God's GPS
      • Touryan, Contolled Fusion
      • Russo, Vaccine and Salvation
      • Bostrom, Short-eared Owl
      • Redkoles, Expect Unexpected
      • Clifford, Boring
      • McFarland, Imposition of Carbon
      • Lemcio, Manis Mastodon
    • Winter 2021 Issue >
      • Winter 2021 Contents >
        • Garte and Albert Letter from the Editors
        • Burnett How iit All Started
        • Isaac Director's Corner
        • Ruppel Herrington, First Editor
        • Burnett Origin of Lire
        • Hearn Balance
        • Middleton Natural Theology
        • Story Antibodies and Randomness
        • Lamoureux I Sleep a Lot
        • Warren Overloaded Brains
        • Isaac Knowledge of Information
        • Bancewicz Wonder and Zebrafish
        • Oord Photoessay
        • Albert Hope in Winter
        • Clifford Storytelling & Drama in Teaching
        • Pohl The Column (Poetry)
    • Fall 2020 Issue >
      • Letter from Editors
      • Pohl, Panpsychism and Microbiome
      • Reyes, Communion During Loss
      • Griffin, Hands On
      • Azarvan, Science and Limits
      • Cornwell, Search Engines for God
      • Thuraisingham, Duality of Humans and Particles
      • Touryan, Prayers of Petition
      • George, Perfect Vision
      • Declare the Glory, Green: Awe
      • Bostrom Purpose
      • Oord, Theological Photoessay
      • Clifford, Food, Water, Waste
    • Summer 2020 Issue >
      • Summer 2020 Contents >
        • Editors Letter Summer2020
        • Jones, Science Faith Duopoly
        • Mix, God and the Virus
        • Warner, COVID-19 and Goodness of Creation
        • Gonzalez, Pandemic and Groaning of Creation
        • Johnson, Star Wars Food
        • Pyle, It Takes a (Medical ) Village
        • Arveson, Use for 3D Printers
        • Peterson, Pandemic and Research
        • Zeidan, Mentorship Online
        • Oleskeiwicz, Dragonfly on Water
        • Carr, COVID-19 and Climate Change
        • Nierrman, The Squirrel
        • Cornwell, COVIS-19 Bucket List
        • Bostrom, Grass Thoughts
        • Clifford, Summ20 Conflict
    • Spring 2020 Issue >
      • Letter from the Editors SP20
      • AD
      • Murphy, Nature and Calvary
      • Dickin, The Flood and Genesis 1
      • Gruenberg, Empiricism and Christian Spirituality
      • Ungureanu, Science, Religion, Protestant Tradition
      • Russo, How does it End?
      • Siegrist, Problems with Materialism
      • Ohlman, 20/20 in 2020
      • Warren, Rock Frogs
      • Edwards, Sanctuary
      • Bostrom, Clothed
      • Clifford, The Lent of Lockdown Spring 2020
      • Hall, 1:30 AM on a Tuesday (Poem)
    • Winter 2020 Issue >
      • Letter from the Editor Winter 2020
      • AD
      • Wimberly Inheritance, Meaning and Code
      • Defoe; A Pastor's Journey
      • Mix The Ends of the World
      • Pevarnik Limits of Physics
      • Greenberg "Godly" Science
      • Pinkham Teleological Thinking
      • Alexanian How to Witness
      • "Declare the Glory" Neal, Cross, Gait
      • Clifford "Across the Pond" Winter 2020
      • Oord "Theological Photoessays" Winter 2020
      • Salviander The Objective Man (Poem)
      • Ohlman Orphan of the Universe (Poem)
      • Lemcio Grey's Anatomy (Poem)
    • Fall 2019 Issue >
      • Letter from the Editor Fall 2019
      • Phillippy Mathematics and God
      • Pohl & Thoelen Databases
      • Garte Limits of Science
      • Mitroka Healthy Lifestyle
      • Sigmon Science and Revelation
      • Mariani Compatibility Creation and Evolution
      • Anders Theistic Evolution
      • Touryan Are we alone
      • Johnson Purpose and Source
      • Declare the Glory Curry, Smith, Best
      • Clifford "Across the Pond" Fall 19
      • Oord "Theological Photoessays Fall 19
      • Eyte Cross Cascade "Poem"
    • Summer 2019 Issue >
      • Letter from the Editor Summer 2019
      • Arveson Is There a “Theory of Everything”
      • Anderson The History and Philosophy of Science and Faith
      • Tolsma Science in Church
      • Salviander Black Holes and Atheism
      • Johnson Practical Problems for Literal Adam
      • Hall God and the Assumptions of Scientific Research
      • Linsky Overcoming Misconceptions
      • Wilder Sanctity of Creation
      • Clifford "Across the Pond" Summer19
      • Oord "Theological Photoessays" Summer 2019
      • Flaig Time and Me (Poem)
    • Spring 2019: Creation Care and Environment >
      • Letter from the Editor Spring 2019
      • Bancewicz;Sustainability Pledge: Why the Environment is My Problem
      • Lin; Environmental Problems as a Place for Compromise and Dialogue
      • Garvey; Where the Fall Really Lies
      • Lewis; Solar-Powered Life: Providing Food, Oxygen and Protection
      • Garte; Time and Human Impact on the Environment
      • Mays; Reforming Science Textbooks
      • Carr; Cosmic Energy First, Then Matter: A Spiritual Ethic
      • Kincanon; The Young Earthers and Leibniz
      • Declare the Glory Gauger
      • Clifford "Across the Pond" Spring 2019
      • Oord; Photoessay. Theological Photo Essays
      • Rivera; Photoessay. Digital Artwork: Images of Jesus
      • Albert; Poem. A Goldfish Sings a Tentative Psalm
      • Armstrong; Poem Holy Sonnet XI
    • Winter 2019: Education and Outreach 2 >
      • Letter from the Editor, Winter 2009
      • Applegate; Project Under Construction: Faith Integration Resource for High School Biology
      • LaBelle; Sidewalk Astronomy Evangelism - Taking it to the Streets!
      • Reed; Speaking to the Heart and Mind of Students about Evolution and Creation
      • Marcus; The Conflict Model
      • Rivera; The Implicit Assumptions behind Hitchen's Razor
      • Russo; Redeeming Bias in Discussion of Science and Faith
      • Fischer; Origins, Genesis and Adam
      • Clifford Column, Winter 2019
      • Gait; Photoessay - Stripes
      • Lee; Poem. In Chaos and Nothingness
    • Fall 2018: Education and Outreach 1 >
      • Letter from the Editor Fall 2018
      • Glaze; A Walk within Two Worlds: Faith, Science, and Evolution Advocacy
      • Johnson; Teaching the Controversy in Texas
      • Cootsona; Mere Christianity, Mainstream Science and Emerging Adults
      • Kindstedt; Creating a Third Culture
      • Zeidan; An Effective Way to Integrate Supportive Communication and Christian Belief into Virtual Classrooms
      • Marshall; A New Model of Causation
      • McClure; Nothing in the Bible Makes Sense Except in the Light of Grace
      • Frank; Christianity, Science and Teamwork
      • Assad/Reyes; Interview. Discovering a Renewed Sense of Awe and Wonder about God
      • Clifford Column Fall 2018
      • Menninga; Photoessay. What do These Stones Mean?
    • Summer 2018: Judgment and Peer Review >
      • Letter from the Editors Summer 2018
      • Jones; Peer Review: Avoiding Judgmentalism
      • Arnold; Discovering Spiritual Information Through Peer-Reviewed Science
      • Peterson; Peering at Double-Blind Peer Review
      • Smith; A Philosophical Influence from the Scientific Revolution on Scientific Judgment
      • Mix; The Poetry of Probability
      • Mobley; Randomness vs. the Providence of God?
      • Gordon; Chances are Good: Design and Chance in Genesis 1
      • Siegrist; But the Multiverse...!
      • Reyes; The Community Table: Interview with Marianne Johnson
      • Clifford Column Summer 2018
      • Hill; Poem. Synthesis
      • Lemcio; Poem. I Could See Where This was Going
      • Oord: Photoessay
    • Spring 2018: Chance & Design >
      • Letter from the Editors
      • Bishop; God, Love and Chance
      • Bonham; Quantum Reflections
      • Spaulding; God as Designer
      • Garte; Teleology in Evolution
      • Hall; God, Chance and Buridan's Ox
      • Pohl; Why We Need a Third Culture in Church
      • Dorman; Liturgical Brain
      • Warren; Galapagos
      • Blanchard; On Christian Science
      • Touryan; The Cross as a Cosmic Filter
    • Winter 2018: Race & Inheritance >
      • A Note from the Editors
      • Essay: “Some Pastoral Considerations of CRISPR CAS 9 Gene Editing” by Mario A Russo
      • Essay: “The Genetics and Theology of Race” by Sy Garte
      • Essay: "Grieve the Segregation of Science" by S. Joshua Swamidass
      • Poem: "Cardboard Man" by Ciara Reyes
      • Featured Interview: “Love Is Risk” with Carolyn Finney
      • Essay & Poem: “Abortion Languages: Love, fear, confusion and loss”
      • Essay: "Why the Church Needs Intersectional Feminism" by Emily Herrington
      • Essay: “Elected to Salvation (and other things?)” by Bill Leonard
      • Essay: “Local Colour: A reflection on family, history, and heritage” by Mike Clifford
      • Interview: Corina Newsome, environmentalist and animal keeper
      • Essay: “Spiritual Kin Selection” by Steve Roels
      • Photo Essay: "Trouble in Paradise: Plastic pollution in the Bahamas" by Grace Swing & Robert D Sluka
      • Essay: “Race & Inheritance: Personal reflections and annotations” by Walt Hearn
      • Interview: Carla Ramos, molecular biologist
      • Clifford Column; Discipine Hopping
      • Lemcio; Waves
      • Harris Artwork
      • Hearn; Eulogy - Beyond Science,
    • Summer 17: Cosmology & Theology >
      • Letter from the Editors: Summer 2017
      • Essay: "The News from My Home Galaxy" by Walt Hearn
      • Interview: "Deep Incarnation & the Cosmos: A Conversation with Niels Henrik Gregersen" by Ciara Reyes & Niels Henrik Gregersen
      • Photo Essay: "Breath & Dust" by Kathleen Eady
      • Essay: "Why the Eagle Nebula Just Doesn’t Do It For Me" by Mike Clifford
      • Essay: "The Cosmos in My Hand" by Lucas Mix
      • Interview: “What is Life? On Earth and Beyond” with Andreas Losch
      • Artwork by Missy Pellone
      • Essay: "When God & Science Hide Reality" by Davis Woodworth
      • Essay: "​In Search of Wonder: A Reflection on Reconciling Medieval and Modern Cosmology" by Monica Bennett
      • Essay: "If Christianity and Cosmology Are in Conflict, Whose Side Is Philosophy on?" by Vaughan Rees
    • Winter/Spring 17: "Flesh & Blood" >
      • Letter from the Editor: Winter/Spring 2017
      • Essay: "Probiotics, Prebiotics, Synbiotics: On microbiomes and the meaning of life" by John F. Pohl
      • Essay: "With All Your Mind" by Paul S. Kindsedt
      • Essay: "The Stuff of Life" by Mike Clifford
      • Essay: "Experiencing God’s Love in a Secular Society: A Christian experience with socialized medicine" by Alison Noble
      • Poem: "The Problem with Pain" by Eugne E. Lemcio
      • Essay: "Thoughts of Death in a Cruel World: Job’s suicidal ideation and the “right” Christian response to depression" by Jennifer Michael Hecht and Emily Herrington
      • Essay: "Tissues at Issue" by Walt Hearn
      • Essay: "The Dilemma of Modern Christianity" by Tony Mitchell
      • Poem: "Light" by Billie Holladay Skelley
      • Essay: "Some Theological Implications of Science: Revisiting the Ant" by Mario A. Russo
    • Summer/Fall 16: "Stewardship of Words" >
      • Letter from the Editor: Summer 2016
      • Levity: "Walt Being Walt: Excerpts from the ASA newsletter" by Walt Hearn (compiled by Jack Haas & Emily Ruppel)
      • Poem: "A Prayer Tribute to Walt and Ginny Hearn" by Paul Fayter
      • Essay: "Authentic Science & Authentic Christian Faith" by Paul Arveson
      • Essay: "On Modern-Day Saints & Epistles" by Emily Ruppel
      • Essay: "​Mathematics and the Religious Impulse" by Karl Giberson
      • Poem: "The Wasteful Gene" by Eugne E. Lemcio
      • Three Poems by Dan Eumurian
      • Excerpts from: "The Dictionary of Daily Life in Biblical and Post-Biblical Antiquity" by Edwin Yamauchi
      • Essay: "A Comprehensible Universe: The blessing from God that makes science possible" by Bob Kaita
      • Poem: "The Epistolarian" by Emily Ruppel
    • Spring 16: "Brain Science" >
      • Letter from the Editor: Spring 2016
      • Essay: "Ancient Q, Modern A (?)" by Walt Hearn
      • Essay: "Souls, Brains and People: Who or what are we?" by Gareth D. Jones
      • Essay: "A Functional Theology of Psychopathology" by Edgar Paul Herrington IV
      • Three Poems by Richard Gillum
      • Essay: "Thoughts of Death in an Unkind World: Job’s suicidal ideation and the “right” Christian response to depression" by Jennifer Michael Hecht
      • Short Story: "Malefic" by Jeffrey Allen Mays
      • Essay: "An Engineer Visits a Mindfulness Workshop" by Mike Clifford
      • Essay: "Traces of Trauma in the Body of Christ: The case of The Place of Refuge" by Elizabeth Hernandez
      • Essay: "Did God ‘Create’ Science? Christianity and the uniqueness of the human brain" by William H. Church
    • Winter 16: "Quantum Physics/Epigenetics" >
      • Letter from the Editor: Winter 2016
      • Essay: "God and the New Evolutionary Biology" by Sy Garte
      • Essay: "Quantum Mechanics and the Question of Divine Knowledge" by Stephen J. Robinson
      • Essay: "Creation Out of... Physics?" by Joshua Scott
      • Essay: "Of Books and Bosons" by Mike Clifford
      • Essay: "Words, Words, Words" by Walt Hearn
      • Poem: "Encountering Ernst Haeckel’s 'Ontogeny Recapitulates Phylogeny'" by Eugene Lemcio
      • Essay: "The Extended Evolutionary Synthesis: New conversations and theological questions at the horizons of modern science" by Michael Burdett
      • Poem: "The Difference" by Emily Ruppel
      • Essay: "Maupertuis's Ghost: Finding God in 'action'" by Colin C. Campbell
    • Fall 15: "Technology" >
      • Letter from the Editor: Fall 2015
      • Essay: "‘Braving the New World (Wide Web): Mapping Theological Response to Media" by Justin A. Bailey
      • Poem: "Entropy and Enthalpy" by Glenn R. McGlaughlin
      • Essay: "‘How Proactive Should Christians Be in Learning about Emerging Biomedical Technologies?" by D. Gareth Jones
      • Essay: "‘Can We Fix It? Erm..." by Mike Clifford
      • Poem: "To My Dear Parents" by Sarah Ruden
      • Essay: "‘Which Side, Lord?" by Walt Hearn
      • Poem: "The Column" by John F. Pohl
      • Essay: "‘Technology and the Church" by Derek Schuurman
      • Poem: "On the Shores of Oroumieh" by Emily Ruppel
      • Essay: "‘Technology as Discipline" by Johnny Wei-Bing Lin
    • Summer 15: "Doubt" >
      • Letter from the Editor: Summer 2015
      • Essay: "‘The Road Not Taken’: A personal reflection on careers, counterfactuals and callings" by Tim Middleton
      • Essay: "The Gift of Doubt in My Life" by Rev. Paul Herrington
      • Poem: "The Marsh Birds" by Sarah Ruden
      • Essay: "On St Brendan and the Pendulum of Postgraduate Study" by Mike Clifford
      • Essay: "Doubt: The Invisible Conversation" by Karl W. Giberson
      • Essay: "Doubt, Faith, and Crevasses on My Mind" by Peter M. J. Hess
      • Poem: "Magdalene" by Leonore Wilson
      • Essay: "Breaking Barriers, Ministering in Relationships, and Exemplifying the Gospel" by Stephen Contakes, et al.
      • Poem: "On the Extinction of Matter Near a Black Hole" by Ruth Hoppin
      • Essay: "Sometimes I Doubt..." by Walt Hearn
      • Essay: "The Risks of Love and Life's Big Questions" by Thomas Jay Oord
    • Spring 15: "Animals/Imago Dei" >
      • Letter from the Editor: Spring 2015
      • Essay: "50 Years of Wilderness: a Christian perspective" by Peter van der Burgt
      • Essay: "All Creatures Great and Small " by Walt Hearn
      • Essay: "Let There Be Less: A Christian musing on nature, faith, and farmers’ markets" by Emily Ruppel
      • Poem: "The New Plant and Animal Kingdoms" by Steve Roels
      • Essay: "Of Wonder and Zebrafish" by Ruth Bancewicz
      • Essay: "The Lion, the Spider and the Image of God" by Mike Clifford
      • Cat Poem 1: "Lullaby for Stomp the Cat" by Sarah Ruden
      • Cat Poem 2: "Letting the Dog In" by Emily Ruppel
      • Cat Poem 3: "Reading on the Couch" by Carol Ruppel
      • Essay: "Angry Discussions: A Wrong Way to Stand for Creation Care or Science Advocacy " by Oscar Gonzalez
      • Essay: "Ethical Eating on a Catholic Campus: Some thoughts from a student of environmental studies" by Grace Mican
    • Winter 15: "Information" >
      • Letter from the Editor: Winter 2015
      • Essay: "What Does it Mean to Know?" by Mark Shelhamer
      • Essay: "Knowledge of Information" by Randy Isaac
      • Photo Essay: "Being Here" by Carol Ruppel
      • Essay: "Truth Anyone?" by Walt Hearn
      • Poem: "Transformation" by Ruth Hoppin
      • Interview: "Unpacking Chance, Providence, and the Abraham's Dice Conference" by Olivia Peterson
      • Essay: "On Knowledge and Information–Tales from an English childhood" by Mike Clifford
      • Poem: "Space Travel" by Ruth Hoppin
      • Essay: "Resuming the Science/Faith Conversation" by Jamin Hubner
    • Archives >
      • Past Contributors
      • Unpublished Materal >
        • Richard Graven A Vision of God
      • Fall 14: "History of Science & Christianity" >
        • Letter from the Editor: Fall 2014
        • Essay: "Orchids: Why the founders of modern science cultivated virtue" by Ruth Bancewicz
        • Essay: "Science Falsely So Called: Fundamentalism and Science" by Edward B. Davis
        • Essay: "The Other 'Atom' in Christianity and Science" by Karissa D Carlson
        • Poem: "The Hermit" by Ciara C. Reyes
        • Essay: "Players" by Walt Hearn
        • Essay: "Using Storytelling and Drama in Engineering Lectures" by Mike Clifford
        • Essay: "Is There Anything Historical About Adam and Eve?" by Mike Beidler
        • Essay: "Finding Harmony in Controversy: The early years of the ASA" by Terry Gray and Emily Ruppel
        • Levity: "Fish n' Chips" by Mike Arnold
        • Essay: "Stories" by Walt Hearn
      • Summer 14: "Christian Women in Science" >
        • Letter from the Editor: Summer 2014
        • Essay: "I Really Did That Work: A brief survey of notable Christian Women in Science" by Lynn Billman
        • Essay: "He + She = We" by Walt Hearn
        • Photo Essay: "The Faces of Nature" by Susan Limone
        • Essay: "On Grass that Withers: Overloaded brains and spiritual discernment" by Janet Warren
        • Interview: "Ancient Humans and Modern Choices" with Briana Pobiner
        • Essay: "Crystallographer, Quaker, Pacifist, & Trailblazing Woman of Science: Kathleen Lonsdale’s Christian Life 'Lived Experimentally'” by Kylie Miller and Stephen M. Contakes
        • Artwork: "Eden, Zion" by Harold Sikkema
        • Essay: "Asking the Right Question" by Dorothy Boorse
        • Interview: "Not So Dry Bones" with Mary Schweitzer
        • Essay: "Is Being a Mother and a Scientist Worth It?" by Abby Hodges
        • Essay: "Playing God: A theological reflection on medicine, divine action, and personhood" by Ann Pederson
        • Column: Great Gravity! "BNL 1976 – 2000 (Part 1)"
      • Spring 14: "G&N: The 2-year tour" >
        • Letter from the Editor: Spring 2014
        • Essay: "Political Science?" by Walt Hearn
        • Comic: "Education"
        • Essay: "Finding Hominids with Kamoya Kimeu" by Fred Heeren
        • Poem: "Ziggurat (and Helix)" by Amy Chai
        • Creative Nonfiction: "One Summer" by Dave Harrity
        • Essay: "Do the Heavens Declare the Glory of God?" by Owen Gingerich
        • Comic: "Miracle Mechanics" by Emily Ruppel
        • Essay: "I Sleep A Lot" by Denis O. Lamoureux
        • Poem: "Angels and RNA" by Walt Hearn
        • Comic: "Seminary"
        • Essay: "The Elegance of Antibodies" by Craig M. Story
        • Photo Essay: "Conversing with Nature" by Thomas Jay Oord
        • Essay: "Under the Tutelage of Trees: Arboreal Lessons on Virtue, Kinship, and Integrity" by Peter M. J. Hess
        • Comic: "Humor"
        • Essay: "Science and Scientism in Biology" by Sy Garte
        • Interview: "Biopsychology and Faith" with Heather Looy
      • Winter 14: "Health & Medicine" >
        • Letter from the Editor: Winter 2014
        • Poem: I Have a Piece of Cow in My Heart
        • Essay: Acts of God: Are all mutations random?
        • Column: Beyond Science
        • Poem: Psalm 1859
        • Essay: The Tao of Departing
        • Essay: The Tao of Departing p 2
        • Photo Essay: Walking in Winter
        • Essay: A Christian Doctor on Evolution, Faith, and Suffering
        • Opinion: Making Friends with Frankencorn
        • Poem: Chiaroscuro
        • Interview: "Biopsychology and Faith" with Heather Looy
        • Essay: "The Elegance of Antibodies"
        • Artwork: "Helix" by Harold Sikkema
        • Column: Great Gravity! "Dissertations and Revelations"
      • Fall 13: "Environmentalism" >
        • Letter from the Editor: Fall 2013
        • Poem: Time
        • Essay: Is there Hope for the Ocean?
        • Artwork: "Earthly Tent" by Harold Sikkema
        • Essay: What is Responsible Eating?
        • Essay: Are We Too Obsessed with Food?
        • Poem: Conversation on Creation
        • Essay: Creation Care from the Perspective of a Conservation Geneticist
        • Essay: Mobilizing Scientists for Environmental Missions
        • Poem: Paleocene Spring
        • Interview: Dorothy Boorse
        • Column: Beyond Science
        • Essay: New Testament Motivation for Environmental Stewardship
        • Poem: Stone of House
        • Column: Great Gravity! "Running the Data"
      • Summer 13: "Science & Creativity" >
        • Column: Beyond Science
        • Letter from the Editor: Summer 2013
        • Column: Faith on the Field
        • Poem: Trying Not to Be Too Sunny
        • Comic: "Work in Progress"
        • Essay: Do the Heavens Declare the Glory of God?
        • Essay: Science, Faith, and Creativity
        • Essay: One Summer
        • Comic: "Miracle Mechanics"
        • Featured Essay: Poetry for Scientists
        • Artwork: "Confluence" by Harold Sikkema
        • Column: Great Gravity! "The Great Ungainly Journey West"
      • Winter 13 >
        • Letter from the Editor: Winter 2013
        • Column: Faith on the Field
        • Comic: "Apples to Apples"
        • Creative Nonfiction: "One Winter"
        • Column: Clearing the Middle Path
        • Essay: Science and Scientism in Biology
        • Poem: "Angels and RNA"
        • Feature Article: I Sleep A Lot
        • Poem: "Fragile"
        • Column: Beyond Science
        • CiS 2012 Student Essay Contest: Runner Up
        • Essay: Why Awe?
        • CiS 2012 Student Essay Contest: First Place
        • Column: Great Gravity! "A Bit of Perspective"
        • Column: Modern Frontiers, Ancient Faith
        • Column: Time Capsule
      • Fall 12 >
        • Letter from the Editor: Fall 2012
        • The Director's Corner
        • Column: Faith on the Field
        • Comic: "Education"
        • Interview: Greetings from Mars!
        • Column: Clearing the Middle Path
        • Photo Essay: "Conversing with Nature"
        • Comic: "Abe"
        • Essay: Evolution and Imago Dei
        • Poem: "Locus Iste"
        • Levity: Beyond Science
        • Essay: God, Occam, and Science
        • Opinion: Humility and Grace
        • Levity: Great Gravity! "The College Years"
        • Poem: "Q.E.D."
        • Essay: My Overlapping Magisteria
        • Column: Time Capsule
      • Summer 12 >
        • Table of Contents
        • Letter from the Editor: Summer 2012
        • Director's Corner
        • Column: Faith on the Field
        • Column: Modern Frontiers, Ancient Faith
        • Comic: "Seminary"
        • Poem: "Temptation in the Wired Wilderness"
        • Levity: Beyond Science
        • Opinion: "The Breaking Bread"
        • Comic: "Humor"
        • Column: Clearing the Middle Path
        • Poem: "Ziggurat (and Helix)"
        • Levity: Great Gravity! "The Grade School Years"
        • Opinion: "Adam and the Origin of Man"
        • Poem: "Missa Solemnis"
        • Column: Time Capsule
      • Spring 12 >
        • Table of Contents
        • Letter from the Editor: Spring 2012
        • Director's corner
        • Column: Faith on the Field
        • Column: Time Capsule
        • Poem: "From Where do We Come?"
        • Featured Scientist
        • Levity: Beyond Science
        • Essay: "Faith and Science"
        • Fiction: "A Matter of Dust"
        • Levity: Great Gravity! "The Early Years"
        • Opinion: "Phony Environmental Theology"
        • Fiction: "Illumination"
        • Interview: "Process"
        • Column: Modern Frontiers, Ancient Faith
    • Spring 13 >
      • Letter from the Editor: Spring 2013
      • Column: Faith on the Field
      • Faith on the Field, cont.
      • Poem: Scientist's Psalm
      • Essay: A Downcast Spirit Dries Up the Bones: More perspectives on depression
      • Artwork: "Lipo Osteo" by Harold Sikkema
      • Feature: The Bible, Evolution, and Grace
      • Column: Beyond Science
      • Book Review: Prisoners of Hope
      • Column: Great Gravity! "The Grad School Years"
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Probiotics, Prebiotics, Synbiotics:  On microbiomes and the meaning of life

By John F Pohl
Picturehttp://evolution.berkeley.edu/evolibrary/article/evo_04
“Just as a body, though one, has many parts, but all its many parts form one body, so it is with Christ. For we were all baptized by[c] one Spirit so as to form one body—whether Jews or Gentiles, slave or free—and we were all given the one Spirit to drink. Even so the body is not made up of one part but of many.” 1 Corinthians 12: 12-14 (NIV)
 
“Again Jesus called the crowd to him and said, “Listen to me, everyone, and understand this. Nothing outside a person can defile them by going into them. Rather, it is what comes out of a person that defiles them.” After he had left the crowd and entered the house, his disciples asked him about this parable. “Are you so dull?” he asked. “Don’t you see that nothing that enters a person from the outside can defile them? For it doesn’t go into their heart but into their stomach, and then out of the body.” Mark 7: 14-19 (NIV)                 
 
Human beings, like all complex animals, are fascinating examples of the multi-layering of organic chemistry and biochemistry pathways. Our cells are eukaryotic organisms (that is, our cells, unlike bacteria, have a nucleus and organelles) covered by a lipid bilayer membrane with proteins protruding through in order to allow communication with the outside world via chemical and electrical gradient signatures.
 
Since our cells are eukaryotes, we apparently have an advantage compared to our prokaryote neighbors (i.e., bacteria) since we have encapsulated organelles and a nucleus, have a larger cell size, and have more genetic information (as in chromosomes filled with DNA) to allow for massive variation during data exchange. One might proudly think that we are a most superior creature. Our eukaryotic cells have come together in a multitude of around 30 trillion to form an adult human. Our cells are a veritable walking coral reef, of sorts, with highly specialized cells working together to allow us to walk, talk, make little ones, and write a paper about our cells. We would appear to be in control…but perhaps not…as we think about the human microbiome. 
 
All sorts of “other” interact with our body on a daily basis, minute by minute, throughout each of our existences on this planet. Billions, if not trillions, of viruses, bacteria, fungi, protists, and the like interact with our body, invade our body, help our body, hurt our body, and even just hang out in our body without ever interacting at all... and we know so little about them. However, these creatures now have been given global terms, including the microbiome (these microbes and their genetic signature) and the microbiota (the taxa identified with these microbes). Research over the past 15-20 years has exploded in this particular area of science, and we are just beginning to understand these creatures, their interactions with us, and what it means to truly be human with billions of organisms constantly interacting with us throughout our body.
 
Terms and Interactions
 
Probiotics are essentially commensal bacteria or fungi normally found interacting with humans (such as in the intestine) that function as “good bacteria” or “good fungi.” Certain Lactobacillus, Bifidobacterium, and Saccharomyces species typically are used as probiotics in over-the-counter supplements. Probiotics compete for niche space against pathogenic bacteria and likely have the ability to modulate our immune system for certain diseases. In fact, evidence suggests that the systemic effects of probiotics may be more profound that we realize. 
 
For example, changing the composition of gut bacteria in patients with cystic fibrosis using probiotics may potentially alter the bacteria in the lungs to less pathogenic agents which could improve lung health. One additional point to consider in the realm of probiotics is the use of fecal transplantation, which is the relatively new technique of providing a large-volume stool transplant from a healthy donor to a sick individual via a feeding tube, enema, or endoscopic technique. This technique has been used successfully to treat specific chronic gastrointestinal infections, such as Clostridium difficile, although the therapeutic effect of fecal transplantation for other gastrointestinal diseases (such as Crohn disease and ulcerative colitis) is not entirely clear and not routinely recommended. 
 
Prebiotics are generally defined as non-absorbed substances which promote the growth of “healthy” bacteria in the intestine similar to those bacteria considered probiotics. Fiber sources, cereal grains such as bran, and polysaccharides such as inulin are known dietary prebiotics. Breast milk, already brimming with antibodies to fight infections, has prebiotic potential as infants fed breast milk typically develop intestinal bacteria that are more beneficial in preventing infections compared to those infants fed solely formula.
 
Synbiotics are simply a combination of pro- and prebiotics.  Because there is such a large number of combinations of such products available, it is somewhat unclear as to what clinical benefit synbiotics provide.
 
Lest we forget, antibiotics are one of major advances in the history of medicine. These are pharmaceutical agents that work via various modes to disrupt cell replication leading to bacterial death. The lay public has likely heard about the tremendous overuse of antibiotics (in humans as well as in farm animals) leading to antibiotic resistance. Additionally, antibiotic use (especially chronic antibiotic use) can disrupt the intestinal microbiome, leading to gastrointestinal infections, such as Clostridium difficile; thus, appropriate antibiotic stewardship is greatly needed worldwide.
 
Therapeutic Benefits
 
Whenever a product that is deemed “natural” becomes available in pharmaceutical or over-the-counter dietary forms, it is often assumed that it is “good for you” even by health care professionals. In many ways, the term “probiotic” is problematic in itself as “pro” has the meaning of “on behalf of.” As a result, there really is an over-abundance of inaccurate advertising regarding the benefits of pro-, pre-, and synbiotics. In reality, most of the effects of these agents in healthy individuals likely are negligible.
 
As a clinician, I find a large amount of the research disjointed and without a clear outcome when I am caring for patients who might benefit from pro-, pre-, or synbiotics. The sheer volume of research in this area is fascinating. A simple search on PubMed for “microbiome” leads to over 26,000 articles while “probiotic” (at the time of this writing) has 17,188 articles, “prebiotic” has 5238 articles, and “symbiotic” has close to 800 articles.
 
There are two aspects of the microbiome in relation to clinical disease that I can discuss as a pediatric gastroenterologist. First, we need to consider necrotizing enterocolitis (known as NEC) which is a significant cause of death and disability in newborn intensive care units (or NICUs), especially in premature infants. The cause of NEC is unknown; however, its etiology is likely multifactorial, including having a thin bowel wall due to prematurity allowing bacteria to more easily cross into the blood stream, an increased risk of blood clotting of the intestinal blood vessels leading to death of the intestine, and excess growth of potentially dangerous bacteria in the intestine (which is known as “bacterial overgrowth”). 
 
When one considers the aspect of bacterial overgrowth, probiotics may have a purpose in preventing NEC. Indeed, there is evidence that probiotic use in such infants may reduce the incidence of NEC by outcompeting the pathogenic bacteria in the intestine while perhaps also having associated antibacterial properties. Additionally, prebiotics may have a similar benefit when one considers one of the most effective prebiotics, breast milk. Breast milk administration to babies at risk of NEC has been shown to be preventative for NEC occurrence. This begs the question: Why are probiotics not used routinely in premature infants? Unfortunately, this question (like many medical questions) has a very complex answer. Human studies are incredibly difficult to perform. There are many ethical, and in my opinion,  potentially moral issues, involved with introducing bacteria into the intestine of potentially critically ill infants. Although some NICUs utilize probiotics on a routine basis, their use is not standardized, and many questions remain about the utility of probiotics in this patient population, including probiotic type, probiotic dosing, duration of probiotic use, and development of algorithms to determine the patient population for which probiotics would be beneficial with a low risk of adverse events.
 
 
The other group for which I see probiotics used is in patients with cystic fibrosis. Cystic fibrosis is caused by a mutation of the cystic fibrosis transmembrane conductance regulator gene (or CFTR gene). A simple way of thinking about cystic fibrosis is that mutations of the CFTR gene lead to thickened secretions throughout the body. Cystic fibrosis is associated with progressive lung disease due to thickened fluid and mucous leading to bacterial colonization of the lungs, inflammation, and increasing lung damage. Since the intestinal tract has a large amount of fluid in it, patients with cystic fibrosis have issues related to bacterial overgrowth in the intestine (although the effect is not as severe as in premature infants with NEC). Regardless, probiotics have been studied in patients with cystic fibrosis and are regularly used for specific symptoms of cystic fibrosis, including abdominal pain, diarrhea, poor intestinal absorption, and fat-soluble vitamin malabsorption, although the true effect of probiotic use in many patients with cystic fibrosis is unknown.
 
Personally, I find the interaction of probiotics in the gut and the potential improvement in lung health of cystic fibrosis very intriguing. The evidence is not very strong as of yet, but there are some preliminary studies which suggest that probiotics given in the intestinal tract may influence the bacteria in the lungs of cystic fibrosis patients leading to less pathogenic bacteria in the lungs and better lung function. The potential association between what cellular signaling occurs between the intestinal tract and lung from probiotic use is fascinating.
 
Finally, I want to discuss the brain. As a pediatric gastroenterologist, I don’t take care of adults, so I am not intimately familiar with Alzheimer’s disease and other forms of dementia outside of dealing with this issue in my own family. When one considers how the gut microbiome may affect lung function, then one has to wonder if there is an association between what is happening in the intestine and what is happening in the central nervous system, especially in the brain. It turns out that scientists are looking into such an association. No clear link is known; however, certain probiotics can decrease overall inflammation in the elderly, and this finding brings up the question as to whether inflammation in the brain could be reduced in the elderly with use of probiotics. One study using rats suggests that probiotic use in the gut can potentially reduce the risk of other brain disorders, such as anxiety and depression. This aspect is extremely fascinating, but we are a long time away before we truly understand the associations involved.
 
The Microbiome and Theology
 
When I first thought about writing this article, I performed a quick search of Google looking for theological considerations of the microbiome. I found almost nothing, and I think this area has much engagement potential for our friends who are theologians. As a physician who is a Christian but not a theologian, I wish to share some ideas that may invite further contemplation.
 
First, our understanding of the human microbiome appears to put an unusual spin on dualism (the idea that minds are separate from the matter they study, in this case the human body). If one considers the growing corpus of research suggesting bacteria (and possibly fungi or viruses in the microbiome) can affect our mental and emotional health, then these insights may have psychological, evolutionary, ecological, and theological consequences regarding what it means to be human and a child of God.
 
Second, the idea of the microbiome affecting our personality, our metabolism, and our susceptibility to various diseases puts a new spin on concepts such as the evolutionary arrival of human beings, our absolute freedom, and the extent of our situatedness. That is, we are embedded in various “levels” of dependency on others. For example, our freedom as “individuals” is contingent on our health, and our health is affected by our microbiome (every one of us is reliant on billions of microscopic creatures for  our metabolism); yet our microbiome is affected by environmental conditions and cultural practices (such as the geographic and social availability of nutrients, communal traditions for eating and drinking, and the social transmission of microorganisms as can occur when sharing a meal).
 
What is a Christian perspective on all of the above? I think the idea of the microbiome interacting with our species allows us to be more specific when we consider Paul’s description of each and every person’s part in the “body of Christ.” Yes, we can be the foot, hand, and eye, but perhaps we can be just as important (although not as obvious) as part of the microbiome of humanity. Our daily Christian walk, specifically how we interact with others around us, may appear to be negligible in a grand sense of the history of the human species, but in the context of “Do to others as you would have them do to you,” learning to see others’ bodies as an extension of our own could make a profound impact.
 
We have learned so much in a relatively short period of time regarding the human microbiome; however, a plethora of unknowns in this field will require further scientific investigation. My personal belief is that eventually we are going to develop individual genomic profiles of a patient’s microbiome in order to treat acute illnesses, but also to prevent chronic disease from occurring or progressing (such as diabetes or coronary artery disease). I also think we are in our infancy in our understanding of the theological impact of the human microbiome, especially in ideas such as “Let us make mankind in our image,” as I believe the microbiome is a synergistic metaphor of how we should love and help each other in our daily existence.
 
 


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 John F. Pohl MD is a professor of pediatrics and a pediatric gastroenterologist at Primary Children’s Hospital (University of Utah) in Salt Lake City, Utah. You can follow John at @Jfpohl on Twitter. John would thank his friend and fellow ASA member, Robert Thoelen, for his helpful edits.
God & Nature magazine is a publication of the American Scientific Affiliation, an international network of Christians in science: www.asa3.org